NDLI: Comparison of Infrared Spectrometer and Mass Spectrometry for 13C-Urea Breath Test in the Diagnosis of Helicobacter pylori Infection

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Comparison of Infrared Spectrometer and Mass Spectrometry for 13C-Urea Breath Test in the Diagnosis of Helicobacter pylori Infection

Content Provider	Semantic Scholar
Author	Peng, Nan-Jing Lo, Ching-Chu Lai, Kwok-Hung Liu, Ren-Shyan Lee, Shui-Cheng Tsay, Daw-Guey Lo, Gin-Ho Hsu, Ping-I
Copyright Year	2004
Abstract	Background: Infrared spectrometer has been developed recently as an alternative tool of mass spectrometry for quantitative gas analysis in 13C-urea breath test (UBT). This investigation is to compare the diagnostic efficacy of infrared spectrometer with mass spectrometry for UBT in the evaluation of Helicobacter pylori (H. pylori) infection. Methods: Sixty-three patients with 114 breath tests were included. Fifty-one patients received both endoscopic UBT and conventional UBT, the others received conventional UBT only. On endoscopic UBT, 13C-urea was injected into the stomach through the working channel of endoscope at the end of endoscopic examination, and breath samples were collected 2 min after consumption of 13C-urea. On conventional UBT, breath samples were collected before and 15 min after consumption of 13C-urea. All samples were analyzed with both infrared spectrometer and mass spectrometry. Results: There was a high agreement of H. pylori-positive and H. pylori-negative on endoscopic UBT (100%) and conventional UBT (95.2%) between infrared spectrometer and mass spectrometry. The quantitative analysis of UBT between infrared spectrometer and mass spectrometry is highly correlated (r = 0.968 on endoscopic UBT, r = 0.974 on conventional UBT). Conclusion: Infrared spectrometer is as effective as mass spectrometry for UBT in the diagnosis and quantitative analysis of H. pylori infection.
Starting Page	69
Ending Page	75
Page Count	7
File Format	PDF HTM / HTML
DOI	10.6332/ANMS.1702.002
Volume Number	17
Alternate Webpage(s)	http://www.snm.org.tw/revista2006/2006-08/journal9409/pdf/v17n2/AnnNuclMedSci04-17-69(2-Peng).pdf
Alternate Webpage(s)	https://doi.org/10.6332/ANMS.1702.002
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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