Loading...
Please wait, while we are loading the content...
Similar Documents
Effect of isoflavone-enriched whole soy milk powder supplementation on bone metabolism in ovariectomized mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kim, So Mi Lee, Hyun Sook Lim, Su-Min Lim, Ji Hoon Ha, Wang-Hyun Jeon, Chang Lae Lee, Jae-Yong Kim, Eun Ji |
| Copyright Year | 2018 |
| Abstract | BACKGROUND/OBJECTIVE There is intense interest in soy isoflavone as a hormone replacement therapy for the prevention of postmenopausal osteoporosis. A new kind of isoflavone-enriched whole soy milk powder (I-WSM) containing more isoflavones than conventional whole soy milk powder was recently developed. The aim of this study was to investigate the effects of I-WSM on bone metabolism in ovariectomized mice. MATERIALS/METHODS Sixty female ICR mice individually underwent ovariectomy (OVX) or a sham operation, and were randomized into six groups of 10 animals each as follows: Sham, OVX, OVX with 2% I-WSM diet, OVX with 10% I-WSM diet, OVX with 20% I-WSM diet, and OVX with 20% WSM diet. After an 8-week treatment period, bone mineral density (BMD), calcium, alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP) 5b, osteocalcin (OC), procollagen 1 N-terminal propeptide (P1NP), and osteoprotegenin (OPG) were analyzed. RESULTS BMD was significantly lower in the OVX group compared to the Sham group but was significantly higher in OVX + 10% I-WSM and OVX + 20% I-WSM groups compared to the OVX group (P < 0.05). Serum calcium concentration significantly increased in the OVX + 10% and 20% I-WSM groups. Serum ALP levels were significantly lower in the OVX + 10% and 20% I-WSM groups compared to the other experimental groups (P < 0.05). OC was significantly reduced in the OVX group compared to the Sham group (P < 0.05), but a dose-dependent increase was observed in the OVX groups supplemented with I-WSM. P1NP and OPG levels were significantly reduced, while TRAP 5b level was significantly elevated in the OVX group compared with the Sham group, which was not affected by I-WSM (P < 0.05). CONCLUSIONS This study suggests that I-WSM supplementation in OVX mice has the effect of preventing BMD reduction and promoting bone formation. Therefore, I-WSM can be used as an effective alternative to postmenopausal osteoporosis prevention. |
| Starting Page | 275 |
| Ending Page | 282 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 30090164v1 |
| Alternate Webpage(s) | https://doi.org/10.4162/nrp.2018.12.4.275 |
| DOI | 10.4162/nrp.2018.12.4.275 |
| Journal | Nutrition research and practice |
| Volume Number | 12 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | ACP5 gene Acid Phosphatase Alkaline Phosphatase BGLAP gene Bone Cysts Bone Mineral Density Test Calcium Contraceptives, Oral Dose-dependent Hormone replacement therapy Osteogenesis Osteoporosis Osteoporosis, Postmenopausal Ovariectomy Promotion (action) Proprotein Protein Tyrosine Phosphatase, Non-Receptor Type 6 SOY ISOFLAVONES Soy Milk Tartrates bone metabolism procollagen Type I N-terminal peptide |
| Content Type | Text |
| Resource Type | Article |
