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Glia-dependent switch of kainate receptor presynaptic action.

Content Provider	Semantic Scholar
Author	Bonfardin, Valérie Delphine Fossat, Pascal Theodosis, Dionysia T. Oliet, Stephane
Copyright Year	2010
Abstract	Presynaptic kainate receptors (KARs) exert a modulatory action on transmitter release. This effect can be switched from facilitation to inhibition by an increased concentration of KAR agonists. We here report that activation of presynaptic GluK1-containing KARs facilitates GABA release on oxytocin and vasopressin neurons in the supraoptic nucleus of the hypothalamus. Increase in ambient levels of glutamate associated with the physiological reduction of astrocytic coverage of oxytocin neurons in lactating rats switches this KAR-mediated facilitation to inhibition of GABAergic transmission. This effect was reproduced in both oxytocin and vasopressin neurons of virgin rats when glutamate transporters were blocked pharmacologically, thereby establishing that enhanced levels of extracellular glutamate induce the switch in KAR-mediated action. The facilitation of GABA release was inhibited with philanthotoxin, a Ca(2+)-permeable KAR antagonist, suggesting that this effect was associated with an ionotropic mode of action. Conversely, KAR-mediated inhibition was compromised in the presence of U73122, a phospholipase C inhibitor, in agreement with the involvement of a metabotropic pathway. We thus reveal that physiological astrocytic plasticity modifies the mode of action of presynaptic KARs, thereby inversing their coupling with GABA release.
Starting Page	3490
Ending Page	3491
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/30/3/985.full.pdf
PubMed reference number	20089907v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.3389-09.2010
DOI	10.1523/jneurosci.3389-09.2010
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	30
Issue Number	3
Language	English
Access Restriction	Open
Subject Keyword	Calcium Cell Nucleus Glutamic Acid HSD17B12 gene Hypothalamic structure Kainate Membrane Transport Proteins Neuroglia Neurons Other and unspecified disorders of the circulatory system Oxytocin Phospholipase C Receptors, Kainic Acid Structure of supraoptic nucleus Switch Device Component TRANSMITTER (Medical Device) U 73122 Vasopressins facilitation gamma-Aminobutyric Acid physical hard work
Content Type	Text
Resource Type	Article

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