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Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Darrasse-Jèze, Guillaume Marodon, Gilles Salomon, Benoît L. Catalá, Martin Klatzmann, David |
| Copyright Year | 2005 |
| Abstract | Little is known about the ontogeny of naturally occurring CD4(+)CD25(+) regulatory/suppressor T cells that play a major role in maintaining self-tolerance in mice and humans. In rodents, thymectomy on day 3 of life leads to multiple organ-specific autoimmune diseases that can be prevented by adoptive transfer of regulatory T cells, suggesting their neonatal development. We investigated regulatory T-cell ontogeny in 11 human fetuses. Together with the first mature T cells, thymic CD4(+)CD25(+) cells were detected as early as 13 weeks of gestation. Thymic CD25(+) cells appeared to be positively selected at the CD4(+)CD8(+)CD3(hi) differentiation stage, as assessed by CD1a and CD69 expression. The proportion of thymic CD4(+)CD25(+) cells appeared quite stable with age, around 6% to 7%, similar to the proportion observed in infant thymi. Extrathymic CD4(+)CD25(+) T cells could hardly be detected at 13 weeks of gestation but were present from week 14 onwards. As adult regulatory T cells, purified CD4(+)CD25(+) fetal cells were anergic and suppressed T-cell proliferative responses; they expressed intracellular cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and Foxp3 mRNA. Altogether, our results indicate that the generation of regulatory/suppressor T cells is consubstantial to the generation of a functional and self-tolerant immune system. |
| Starting Page | 110 |
| Ending Page | 116 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/105/12/4715.full.pdf?sso-checked=true |
| PubMed reference number | 15731180v1 |
| Volume Number | 105 |
| Issue Number | 12 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adoptive Transfer Autoimmune Diseases Cell Ontogeny Fetus Growth Immune system Leukemia, B-Cell Minor Lymphocyte Stimulatory Antigens T-Lymphocyte Thymectomy Thymus Neoplasms extrathymic T cell selection |
| Content Type | Text |
| Resource Type | Article |
