NDLI: Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer.

Please wait, while we are loading the content...

Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer.

Content Provider	Semantic Scholar
Author	Pan, Ping-Ying Weber, Ksenia Ozao-Choy, Junko Wang, George Xun Yin, Bingjiao Divino, Celia M. Chen, Shu-hsia
Copyright Year	2010
Abstract	Immune tolerance to tumors is often associated with accumulation of myeloid-derived suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In tumor-bearing mice, MDSCs can themselves facilitate the generation of tumor-specific Tregs. In this study, we demonstrate that expression of the immune stimulatory receptor CD40 on MDSCs is required to induce T-cell tolerance and Treg accumulation. In an immune reconstitution model, adoptive transfer of Gr-1+CD115+ monocytic MDSCs derived from CD40-deficient mice failed to recapitulate the ability of wild-type MDSCs to induce tolerance and Treg development in vivo. Agonistic anti-CD40 antibodies phenocopied the effect of CD40 deficiency and also improved the therapeutic efficacy of IL-12 and 4-1BB immunotherapy in the treatment of advanced tumors. Our findings suggest that CD40 is essential not only for MDSC-mediated immune suppression but also for tumor-specific Treg expansion. Blockade of CD40-CD40L interaction between MDSC and Treg may provide a new strategy to ablate tumoral immune suppression and thereby heighten responses to immunotherapy.
Starting Page	99
Ending Page	108
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/70/1/99.full.pdf
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/early/2009/12/08/0008-5472.CAN-09-1882.full.pdf
PubMed reference number	19996287v1
Alternate Webpage(s)	https://doi.org/10.1158/0008-5472.CAN-09-1882
DOI	10.1158/0008-5472.can-09-1882
Journal	Cancer research
Volume Number	70
Issue Number	1
Language	English
Access Restriction	Open
Subject Keyword	Adoptive Transfer Fucosidase Deficiency Disease Immune Tolerance Immunotherapy Leukemia, B-Cell Monocytes Myeloid-Derived Suppressor Cells Neoplasms T-Lymphocyte
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses.

Myeloid-derived suppressor cells and the efficacy of $CD8^{+}$T-cell immunotherapy

Monitoring regulatory immune responses in tumor immunotherapy clinical trials

BRAF-inhibition and tumor immune suppression

Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.

Myeloid-derived suppressor cells as regulators of the immune system.

Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression.

Myeloid-Derived Suppressor Cells: Implications in the Resistance of Malignant Tumors to T Cell-Based Immunotherapy

Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer.

Similar Documents

Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses.

Myeloid-derived suppressor cells and the efficacy of $CD8^{+}$T-cell immunotherapy

Monitoring regulatory immune responses in tumor immunotherapy clinical trials

BRAF-inhibition and tumor immune suppression

Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.

Myeloid-derived suppressor cells as regulators of the immune system.

Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression.

Myeloid-Derived Suppressor Cells: Implications in the Resistance of Malignant Tumors to T Cell-Based Immunotherapy

Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer.