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Empathie und Polymorphismen im Oxytocin- und Oxytocinrezeptor-Gen bei Patienten mit Schizophrenie
| Content Provider | Semantic Scholar |
|---|---|
| Author | Brockmann, Eva-Maria |
| Copyright Year | 2016 |
| Abstract | Objectives: Deficits in empathic abilities are an important clinical feature of schizophrenia and predict the functional outcome of the disease. In contrast to cognitive components, affective components of empathy are less well understood. Oxytocin (OXT) and Oxytocin receptor (OXTR) gene polymorphisms have already been associated with diseases marked by socioemotional deficits as well as social cognition and empathy in healthy individuals. In three studies we investigated an association of different single nucleotide polymorphisms (SNPs) within the OXT and OXTR gene with schizophrenia, their possible influence on empathy in schizophrenia, furthermore affective and cognitive components of empathy in the context of the subjective experience of emotion processing in schizophrenia and their influence on psychosocial function. Methods: Two SNPs within the OXT gene and five SNPs within the OXTR gene were genotyped in schizophrenic patients and healthy controls. We used the Interpersonal Reactivity Index (IRI) and Multifaceted Empathy Test (MET) as empathy measures, the Subjective Experience of Emotion Scale (SEE) and Emotional Contagion Scale (ECS) to assess emotional contagion and aspects of emotion processing. Results: We found a significant association of OXTR SNP rs53576 (A>G) and OXTR SNP rs237885 (T>G) with schizophrenia and a significant influence of OXTR SNP rs2254298 on IRI „empathic concern“, representing affective empathy. Patients showed impaired cognitive but not affective empathy. They reported more negative emotional contagion, more lack of emotions and overwhelming emotions, more symbolization of emotions by imagination and less self-control compared to healthy controls. Psychosocial function was predicted by cognitive empathy, less interpersonal distress and the experience of a higher extent of overwhelming emotions. Conclusions: The results suggest a possible influence of oxytocin system genes on schizophrenia vulnerability and an association of OXTR gene polymorphisms with affective empathy in schizophrenia. They indicate that aspects of emotion processing have an important effect on empathic abilities in schizophrenia and illustrate the importance of subjective processes of managing negative emotions as those predict psychosocial outcome. |
| File Format | PDF HTM / HTML |
| DOI | 10.17169/refubium-7304 |
| Alternate Webpage(s) | https://refubium.fu-berlin.de/bitstream/handle/fub188/3104/diss_e-m.brockmann.pdf?isAllowed=y&save=y&sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.17169/refubium-7304 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
