NDLI: Intense near-infrared-II luminescence from NaCeF4:Er/Yb nanoprobes for in vitro bioassay and in vivo bioimaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00927a

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Intense near-infrared-II luminescence from NaCeF4:Er/Yb nanoprobes for in vitro bioassay and in vivo bioimaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00927a

Content Provider	Semantic Scholar
Author	Lei, Xialian Li, Renfu Tu, Datao Shang, Xiaoying You, Wenwu Sun, Caixia Zhang, Fan Chen, Xueyuan
Copyright Year	2018
Abstract	Near-infrared (NIR) II luminescence between 1000 and 1700 nm has attracted reviving interest for biosensing due to its unique advantages such as deep-tissue penetration and high spatial resolution. Traditional NIR-II probes such as organic fluorophores usually suffer from poor photostability and potential long-term toxicity. Herein, we report the controlled synthesis of monodisperse NaCeF4:Er/Yb nanocrystals (NCs) that exhibit intense NIR-II emission upon excitation at 980 nm. Ce3+ in the host lattice was found to enhance the luminescence of Er3+ at 1530 nm with a maximum NIR-II quantum yield of 32.8%, which is the highest among Er3+-activated nanoprobes. Particularly, by utilizing the intense NIR-II emission of NaCeF4:Er/Yb NCs, we demonstrated their application as sensitive homogeneous bioprobes to detect uric acid with the limit of detection down to 25.6 nM. Furthermore, the probe was detectable in tissues at depths of up to 10 mm, which enabled in vivo imaging of mouse organs and hindlimbs with high resolution, thus revealing the great potential of these NaCeF4:Er/Yb nanoprobes in deep-tissue diagnosis.
Starting Page	4682
Ending Page	4688
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1039/c8sc00927a
PubMed reference number	29899962
Journal	Medline
Volume Number	9
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/sc/c8sc00927a/c8sc00927a1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c8sc00927a
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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