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Combining Copper‐Catalyzed Hydroboration with Palladium‐Catalyzed Suzuki Coupling for the One‐pot Synthesis of Arylallylamines under Micellar Conditions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Horn, Pedro De Andrade Braun, Roger Isoppo, Victória Goulart Costa, Jessie Sobieski Da Lüdtke, Diogo S. Moro, Angélica Venturini |
| Copyright Year | 2017 |
| Abstract | Herein we report the one-pot dual-metal catalytic synthesis of arylallylamines, by combination of a Cu-catalyzed hydroboration with a Pdcatalyzed Suzuki arylation, using a broad range of aryl halides. Importantly, the reaction sequence was entirely performed in water, in the presence of small amounts of SPGS-550M, without the need of solvent switch or addition of organic co-solvents, rendering it operationally simple and environmentally benign. The usefulness of this methodology was highlighted in a short synthesis of the pharmaceutically important compound naftifine. |
| Starting Page | 2322 |
| Ending Page | 2328 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/adsc.201700094 |
| Volume Number | 359 |
| Alternate Webpage(s) | http://pdf.xuebalib.com:1262/2do9RJZTmC2z.pdf?down |
| Alternate Webpage(s) | https://doi.org/10.1002/adsc.201700094 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
