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Variability of QT interval duration in obstructive sleep apnea: an indicator of disease severity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Baumert, Mathias Smith, Janet H. Catcheside, Peter G. Mcevoy, R. Douglas Abbott, Derek Sanders, Prashanthan Nalivaiko, Eugene |
| Copyright Year | 2008 |
| Abstract | STUDY OBJECTIVE To determine OSA-related changes in variability of QT interval duration and in heart rate variability (HRV), and to evaluate the relationship of these parameters to disease severity. DESIGN Retrospective analysis of diagnostic sleep records. SETTINGS Clinical sleep laboratory in a hospital setting. PATIENTS Twenty patients (12 males and 8 females) without significant comorbidities who were undergoing polysomnography were studied. MEASUREMENTS AND RESULTS Standard heart rate variability measures and QT variability (Berger algorithm) were computed over consecutive 5-minute ECG epochs throughout the night. The effect of sleep stage and the relationship between these parameters and the severity of OSA as determined by the respiratory disturbance index (RDI) were explored. Further, a linear regression model of QT variability was developed. Severity of OSA (RDI) was 49 +/- 28 (range from 17-107) events/ hr. QT variability was the only ECG measure significantly correlated with RDI (both log-transformed; r = 0.6, P = 0.006). Further, QT variability was correlated with the minimum oxygen saturation (r = -0.55, P = 0.01). Sleep stage showed a significant effect on HRV, but not on QT variability. In the regression model, RDI was the strongest predictor of QT variability (R2 increase 38%), followed by high and low frequency power of HRV (R2 increase 10% each). CONCLUSION Obstructive sleep apnea is associated with changes in QT interval variability during sleep. The variance of beat-to-beat QT intervals correlates more strongly with the severity of OSA (as determined by RDI) than standard measures of heart rate variability, and is correlated with blood oxygenation, but not sleep stage. |
| Starting Page | 2991 |
| Ending Page | 3001 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.eleceng.adelaide.edu.au/personal/dabbott/publications/SLP_baumert2008.pdf |
| PubMed reference number | 18652091v1 |
| Volume Number | 31 |
| Issue Number | 7 |
| Journal | Sleep |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cell Respiration Electrocardiography Forty Nine Heart failure OSA protein, Drosophila Oxygen saturation test result Patients QT interval feature (observable entity) Respiratory Distress Syndrome, Adult Sample Variance Seizures Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Stages Standard deviation Sudden Cardiac Death |
| Content Type | Text |
| Resource Type | Article |
