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Application of the Variance Delay Fuzzy Approximate Entropy for Autonomic Nervous System Fluctuation Analysis in Obstructive Sleep Apnea Patients
| Content Provider | MDPI |
|---|---|
| Author | Li, Yifan Wu, Shan Yang, Quanan Liu, Guanzheng Ge, Leijiao |
| Copyright Year | 2020 |
| Description | Obstructive sleep apnea (OSA) is a fatal respiratory disease occurring in sleep. OSA can induce declined heart rate variability (HRV) and was reported to have autonomic nerve system (ANS) dysfunction. Variance delay fuzzy approximate entropy (VD_fApEn) was proposed as a nonlinear index to study the fluctuation change of ANS in OSA patients. Sixty electrocardiogram (ECG) recordings of the PhysioNet database (20 normal, 14 mild-moderate OSA, and 26 severe OSA) were intercepted for 6 h and divided into 5-min segments. HRV analysis were adopted in traditional frequency domain, and nonlinear HRV indices were also calculated. Among these indices, VD_fApEn could significantly differentiate among the three groups (p < 0.05) compared with the ratio of low frequency power and high frequency power (LF/HF ratio) and fuzzy approximate entropy (fApEn). Moreover, the VD_fApEn (90%) reached a higher OSA screening accuracy compared with LF/HF ratio (80%) and fApEn (78.3%). Therefore, VD_fApEn provides a potential clinical method for ANS fluctuation analysis in OSA patients and OSA severity analysis. |
| Starting Page | 915 |
| e-ISSN | 10994300 |
| DOI | 10.3390/e22090915 |
| Journal | Entropy |
| Issue Number | 9 |
| Volume Number | 22 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-08-21 |
| Access Restriction | Open |
| Subject Keyword | Entropy Medical Informatics Obstructive Sleep Apnea (osa) Autonomic Nerve System (ans) Fluctuation Osa Severity Analysis Heart Rate Variability (hrv) Variance Delay Fuzzy Approximate Entropy (vd_fapen) |
| Content Type | Text |
| Resource Type | Article |
