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Early outcome after sirolimus-eluting stent implantation in patients with acute coronary syndromes: insights from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lemos, Pedro Alves Lee, Chi-Hang Degertekin, Muzaffer Saia, Francesco Tanabe, Kengo Arampatzis, Chourmouzios A. Hoye, Angela J. Duuren, Marco Van Sianos, Giorgios Smits, P. C. Feyter, Pim J. De Giessen, Willem J. Van Der Domburg, Ron Theodoor Van Serruys, Patrick Washington |
| Copyright Year | 2003 |
| Abstract | OBJECTIVES This study evaluated the early outcomes of patients with acute coronary syndromes (ACS) treated with sirolimus-eluting stents (SES). BACKGROUND The safety of SES implantation in patients with a high risk for early thrombotic complications is currently unknown. METHODS Sirolimus-eluting stents have been utilized as the device of choice for all percutaneous procedures in our institution, as part of the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry. After four months of enrollment, 198 patients with ACS had been treated exclusively with SES (64% of those treated in the period) and were compared with a control group composed of 301 consecutive patients treated with bare stents in the same time period immediately before this study. The incidence of major adverse cardiac events (MACE) during the first month was evaluated (death, nonfatal myocardial infarction [MI], or re-intervention). RESULTS Compared with control patients, patients treated with SES had more primary angioplasty (95% vs. 77%; p < 0.01), more bifurcation stenting (13% vs. 5%; p < 0.01), less previous MI (28% vs. 45%; p < 0.01), and less glycoprotein IIb/IIIa inhibitor utilization (27% vs. 42%; p < 0.01). The 30-day MACE rate was similar between both groups (SES 6.1% vs. control patients 6.6%; p = 0.8), with most complications occurring during the first week. Stent thrombosis occurred in 0.5% of SES patients and in 1.7% of control patients (p = 0.4). In multivariate analysis, SES utilization did not influence the incidence of MACE (odds ratio 1.0 [95% confidence interval: 0.4 to 2.2]; p = 0.97). CONCLUSIONS Sirolimus-eluting stent implantation for patients with ACS is safe, with early outcomes comparable with bare metal stents. |
| Starting Page | 54 |
| Ending Page | 63 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.onlinejacc.org/content/accj/41/11/2093.full.pdf |
| PubMed reference number | 12798587v1 |
| Volume Number | 41 |
| Issue Number | 11 |
| Journal | Journal of the American College of Cardiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Coronary Syndrome Artificial cardiac pacemaker Bifurcation (procedure) Cardiology discipline Cessation of life Confidence Intervals Email Myocardial Infarction Patients Platelet glycoprotein IIb-IIIa Ab:PrThr:Pt:Ser:Ord Registries Reprint Sirolimus Stent Device Component Stent, device Thrombosis Thrombotic Microangiopathies |
| Content Type | Text |
| Resource Type | Article |
