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Unrestricted utilization of sirolimus-eluting stents compared with conventional bare stent implantation in the "real world": the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lemos, Pedro Alves Serruys, Patrick W. Domburg, Ron T. Van Saia, Francesco Arampatzis, Chourmouzios A. Hoye, Angela Değertekin, Muzaffer Tanabe, Kengo Daemen, Joost Liu, Tommy Mcfadden, Eugene Sianos, Georgios Hofma, Sjoerd H. Smits, Pieter Cornelis Giessen, Willem J. Van Der Feyter, Pim J. De |
| Copyright Year | 2004 |
| Abstract | BACKGROUND The effectiveness of sirolimus-eluting stents in unselected patients treated in the daily practice is currently unknown. METHODS AND RESULTS Sirolimus-eluting stent implantation has been used as the default strategy for all percutaneous procedures in our hospital as part of the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry. Consecutive patients with de novo lesions (n=508) treated exclusively with sirolimus-eluting stents (SES group) were compared with 450 patients who received bare stents in the period just before (pre-SES group). Patients in the SES group more frequently had multivessel disease, more type C lesions, received more stents, and had more bifurcation stenting. At 1 year, the cumulative rate of major adverse cardiac events (death, myocardial infarction, or target vessel revascularization) was 9.7% in the SES group and 14.8% in the pre-SES group (hazard ratio [HR], 0.62 [95% CI, 0.44 to 0.89]; P=0.008). The 1-year risk of clinically driven target vessel revascularization in the SES group and in the pre-SES group was 3.7% versus 10.9%, respectively (HR, 0.35 [95% CI, 0.21 to 0.57]; P<0.001). CONCLUSIONS Unrestricted utilization of sirolimus-eluting stents in the "real world" is safe and effective in reducing both repeat revascularization and major adverse cardiac events at 1 year compared with bare stent implantation. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 14691037 |
| Journal | Medline |
| Volume Number | 109 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/109/2/190.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/109/2/190.full.pdf?download=true |
| Alternate Webpage(s) | https://doi.org/10.1161/01.CIR.0000109138.84579.FA |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
