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Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Caan, Bette J. Emond, J. Natarajan, Loki Castillo, Adrienne L. Gunderson, Erica P. Habel, Laurel A. Jones, Lovell Newman, Vicky A. Rock, Cheryl L. Slattery, Martha L. Stefanick, Marcia L. Sternfeld, Barbara Thomson, Cynthia A. Pierce, John P. |
| Copyright Year | 2006 |
| Abstract | SummaryPurposeTo examine whether weight gain after diagnosis of breast cancer affects the risk of breast cancer recurrence.Patient and methodsPatients included 3215 women diagnosed with early stage breast cancer (Stage I >1 cm., II, and IIIA) who were enrolled either in an observational cohort of breast cancer survivors or were part of the comparison group of a dietary intervention trial to prevent breast cancer recurrence. We computed weight change from 1 year prior to diagnosis to study enrollment. Delayed entry Cox proportional hazards models were used to evaluate associations of categories of weight change with time to recurrence, controlling for known prognostic factors.ResultsNeither moderate (5–10%) nor large (> 10%) weight gain (HR 0.8, 95% CI, 0.6–1.1; HR 0.9, 95% CI, 0.7–1.2, respectively) after breast cancer diagnosis was associated with an increased risk of breast cancer recurrence in the early years post-diagnosis (median time of 73.7 months from diagnosis).ConclusionOur research provides evidence that weight gain commonly seen in the first several years following a breast cancer diagnosis does not increase a woman’s risk for breast cancer recurrence in the first 5–7 years post-diagnosis. However, this research does not address the effects of weight gain on overall survival or on the risk of other new cancers, other prognostic outcomes of concern to the breast cancer survivor. |
| Starting Page | 47 |
| Ending Page | 57 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s10549-006-9179-y |
| Alternate Webpage(s) | https://cloudfront.escholarship.org/dist/prd/content/qt24d495bz/qt24d495bz.pdf?t=lnrszp |
| PubMed reference number | 16541317 |
| Alternate Webpage(s) | https://doi.org/10.1007/s10549-006-9179-y |
| Journal | Medline |
| Volume Number | 99 |
| Journal | Breast Cancer Research and Treatment |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
