A Prospective Study of Weight Gain in Women Diagnosed with Early-Stage Invasive Breast Cancer, Ductal Carcinoma In Situ, and Women Without Breast Cancer.

Content Provider	Europe PMC
Author	Ekenga, Christine C. Wang, Xiaoyan Pérez, Maria Schootman, Mario Jeffe, Donna B.
Copyright Year	2020
Abstract	Background: Weight gain after breast cancer has been associated with recurrence and mortality. We therefore examined factors associated with ≥5% weight gain over 2-year follow-up of a cohort of newly diagnosed early-stage invasive breast cancer (EIBC) and ductal carcinoma in situ (DCIS) patients and age-matched controls without a breast cancer history. Materials and Methods: We interviewed participants 4–6 weeks after definitive surgical treatment (patients) or a negative/benign screening mammogram (controls). Multivariable logistic regression models were used to identify socioeconomic, psychosocial, and treatment factors associated with ≥5% weight gain over 2-year follow-up. Results: Overall, 88 (24%) of 362 EIBC patients, 31 (17%) of 178 DCIS patients, and 82 (15%) of 541 controls had ≥5% weight gain during follow-up. EIBC patients were more likely to experience ≥5% weight gain than DCIS patients (Odds ratio [OR] = 2.16; 95% confidence interval [95% CI] = 1.19–3.95) and controls (OR = 1.76; 95% CI = 1.23–2.51). Among EIBC patients, older patients (OR = 0.96; 95% CI = 0.93–0.99), patients who underwent endocrine therapy (OR = 0.43; 95% CI = 0.19–0.95), smokers (OR = 0.35; 95% CI = 0.14–0.86), and African Americans (OR = 0.23; 95% CI = 0.09–0.58) were less likely to have ≥5% weight gain than their respective counterparts. Among DCIS patients, older patients (OR = 0.94; 95% CI = 0.89–0.99) were less likely to have ≥5% weight gain. Among controls, smokers were more likely to have ≥5% weight gain (OR = 3.03; 95% CI = 1.49–6.17). Conclusions: EIBC patients were more likely than DCIS patients and controls to experience ≥5% weight gain over follow-up. Studies are necessary to elucidate mechanisms of weight gain in early-stage breast cancer survivors.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7194326&blobtype=pdf
Page Count	10
ISSN	15409996
Volume Number	29
DOI	10.1089/jwh.2018.7638
PubMed Central reference number	PMC7194326
Issue Number	4
PubMed reference number	31460829
Journal	Journal of Women's Health [J Womens Health (Larchmt)]
e-ISSN	1931843X
Language	English
Publisher	Mary Ann Liebert, Inc., publishers
Publisher Date	2019-08-28
Publisher Place	USA
Access Restriction	Open
Rights License	Copyright 2020, Mary Ann Liebert, Inc., publishers
Subject Keyword	breast cancer weight gain ductal carcinoma in situ (DCIS) early-stage breast cancer (EIBC) estrogen receptor
Content Type	Text
Resource Type	Article
Subject	Medicine