NDLI: Antiproliferative and anti-inflammatory furostanol saponins from the rhizomes of Tupistra chinensis

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Antiproliferative and anti-inflammatory furostanol saponins from the rhizomes of Tupistra chinensis

Content Provider	Semantic Scholar
Author	Xiang, Limin Wang, Yihai Yi, Xiaomin He, Xiangjiu
Copyright Year	2016
Abstract	Phytochemical investigations of the rhizome of Tupistra chinensis led to the isolation of ten new furostanol saponins along with fourteen known spirostanols. Their chemical structures were elucidated on the basis of spectroscopic and chemical methods, including IR, NMR, MS, and GC analyses. The antiproliferative effects against FaDu and Detroit 562 cell lines and inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in a macrophage cell line RAW 264.7 were assayed for all the isolated compounds. Compound 14 exhibited significant antiproliferative effects against FaDu and Detroit 562 cells with IC50 values of 1.1±0.1 and 1.2±0.1μM, respectively. Compounds 1, 2, 6, 13, 16, 19 and 24 exhibited inhibitory effects on NO production with IC50 values ranging from 15.7 to 46.2μM.
Starting Page	28
Ending Page	37
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1016/j.steroids.2016.10.005
PubMed reference number	27770616
Journal	Medline
Volume Number	116
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0039128X1630157X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0039128X1630157X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.steroids.2016.10.005
Journal	Steroids
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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