NDLI: Rare Multidrug-Resistant Pulmonary Nocardiosis in AIDS

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Rare Multidrug-Resistant Pulmonary Nocardiosis in AIDS

Content Provider	Semantic Scholar
Author	Onaiwu, Cherry O. Velagapudi, Manasa Sarsam, Luay Utley, Lindsay Bricker, Lauren Weiss Bendi, Venkata Sunil Vivekanandan, Renuga
Copyright Year	2017
Abstract	Nocardiosis is an opportunistic infection in patients with depressed cell-mediated immunity. Inhalation is the primary route for exposure via dust particles. Patients with acquired immune deficiency syndrome (AIDS) are at increased risk of disseminated disease. A challenge in the diagnosis of pulmonary nocardiosis is that it can mimic other pulmonary diseases. Nocardia farcinica tends to be a more virulent, multidrug-resistant strain with an increased tendency to disseminate. This report describes a 64-year-old man with AIDS found to have pulmonary nocardiosis that did not respond to standard antibiotic therapy. Further evaluation revealed the virulent, multidrug-resistant Nocardia farcinica species. Targeted antibiotic therapy was initiated, after which the patient had an improvement in pulmonary symptoms. It is important to suspect pulmonary nocardiosis in immunocompromised patients who fail to respond to standard antimicrobial therapy. Susceptibilities should be obtained so that appropriate therapy can be promptly initiated as Nocardia farcinica is highly resistant to multiple antimicrobials.
Starting Page	403
Ending Page	407
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://assets.cureus.com/uploads/case_report/pdf/9323/1515693001-20180111-9887-12v3hmz.pdf
PubMed reference number	29344434v1
Alternate Webpage(s)	https://doi.org/10.7759/cureus.1839
DOI	10.7759/cureus.1839
Journal	Cureus
Volume Number	9
Language	English
Access Restriction	Open
Subject Keyword	Acquired Immunodeficiency Syndrome Antibiotic therapy Cellular Immunity Depressive disorder Disease susceptibility Idiopathic Pulmonary Fibrosis Immunologic Deficiency Syndromes Lung diseases Microbicides Nocardia Infections Nocardia farcinica Opportunistic Infections Patients Pulmonary Nocardiosis Pulmonary Valve Insufficiency Tuberculosis, Pulmonary
Content Type	Text
Resource Type	Article

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