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Nosocomial spread of human immunodeficiency virus-related multidrug-resistant tuberculosis in Buenos Aires.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ritacco, Viviana Lonardo, Martha Di Reniero, Ana Ambroggi, Martha Barrera, Lucia E. Dambrosi, Alicia López, Beatriz Isola, Nélida Kantor, Isabel N. De |
| Copyright Year | 1997 |
| Abstract | A steep upsurge of human immunodeficiency virus (HIV)-associated multidrug-resistant tuberculosis (MDR-TB) was recently observed at a referral treatment center in Buenos Aires City. Between January 1994 and June 1995, TB isolates resistant to at least five drugs were recovered from 101 of 272 HIV-infected inpatients. Highly resistant isolates from 77 patients underwent restriction fragment length polymorphism study with IS6110. After cross-contamination was eliminated, a single TB strain was found to have caused disease in 68 patients with a history of on-site exposure. The frequency of smear-positive pulmonary disease was higher among these patients than among non-MDR-TB HIV-infected patients (50/68 vs. 60/148, P < .001), and the 1-year survival was dramatically reduced (5/68 vs. 92/148). The strain involved in the outbreak was traced back to patients hospitalized in 1992. Institutional infection control policies were and may still be inadequate to contain the spread of TB among immunodepressed subjects, as is the case in other large urban hospitals in Argentina. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/176/3/10.1086/514084/2/176-3-637.pdf?Expires=1492543726&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=AhN5Wi1myYmBBYssKZMCqU-2lxtju2O0l3VeOarrir85ZV3l7r63MnQsZCjneMpabIGMz6nll0pStQWTG~37benAdmSFrK-Zqi7BTYHCbwhcNyKG-96Y-Sfkw43FmCB1BQBqoSUlqv7MXD3qIYaQu1VWRM8wnAQSCYTx0FfldW2E1Z2AfpfGpKlQaQ4QbSFcta~JZeLnCihKuDgOZI8xTjmr~NWSDw7Gig1X-OCb32Y5yCRTpWk18mXpBZiGGIxex5ON7ci0Q8MY3yHR5GXAImak3PvI1RWfIR7xyEUEi0K6j28Ll6eSFxP-LaTZzAvGeMbMiCJVIzn9oMVnfKOnbw__ |
| PubMed reference number | 9291309v1 |
| Volume Number | 176 |
| Issue Number | 3 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 101 Mouse HIV Infections Hospitals, Urban Immunologic Deficiency Syndromes Infectious disease prevention / control Lung diseases Patients Tuberculosis, Meningeal Tuberculosis, Multidrug-Resistant inpatient |
| Content Type | Text |
| Resource Type | Article |
