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Moderate renal dysfunction is not associated with elevated Troponin T in acute coronary syndromes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Correia, Luís Cláudio Lemos Barbosa, Carolina Esteves Cerqueira, Thais M. Vasconcelos, Ana Klyssia Martins Merelles, Saulo Reis, Tiago Alexandre Custódio Lima, José Carlos Carneiro Esteves, José Péricles Teixeira, Marcela S. |
| Copyright Year | 2010 |
| Abstract | BACKGROUND Interpretation of troponin results in patients with acute coronary syndromes (ACS) and renal disease is confused by the fact that renal dysfunction increases troponin levels, regardless of myocardial necrosis. Although it has been demonstrated that end-stage renal disease is associated with elevated cardiac troponin T (cTnT) levels, it is not known whether this biomarker is altered by less than severe degrees of renal impairment. OBJECTIVE To evaluate whether moderate renal dysfunction is associated with cTnT elevation in patients with ACS. METHODS One hundred, forty-five individuals with ACS and creatinine clearance > 30 ml/min were studied. Creatinine clearance was estimated by the Cockcroft-Gault formula and cTnT was measured at hospital admission. Moderate renal dysfunction was defined as a creatinine clearance of 30-59 ml/min and positive cTnT as levels > 0.01 ug/l. RESULTS No correlation was observed between creatinine clearance and cTnT (r = - 0.06, P=0.45). The levels of cTnT were similar among individuals in the first (median=0.05 ug/l), second (median=0 ug/l), third (median=0.07 ug/l) and fourth quartiles (median=0 ug/l) of creatinine clearance - P=0.63. Similarly, there was no difference in troponin values between individuals with moderate renal dysfunction (median=0.02 ug/l) and individuals with normal/near normal function (median=0.03 ug/l) - P=0.63. The prevalence of positive cTnT was similar between individuals with moderate renal dysfunction and normal/near normal renal function (55% vs 52%, P=0.65). CONCLUSION Moderate renal dysfunction is not associated with cTnT elevation in patients with ACS. |
| Starting Page | 56 |
| Ending Page | 60 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.scielo.br/pdf/abc/2010nahead/en_aop10710.pdf |
| PubMed reference number | 21225113v1 |
| Volume Number | 95 |
| Issue Number | 5 |
| Journal | Arquivos brasileiros de cardiologia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Coronary Syndrome Biological Markers Cardiomyopathies Confusion Creatinine Fifty Nine Hospital admission Kidney Diseases Kidney Failure, Chronic Microgram per Liter Milliliter per Minute Necrosis Patients Renal Insufficiency Troponin T, Cardiac Muscle |
| Content Type | Text |
| Resource Type | Article |
