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Cardiac troponin I. A marker with high specificity for cardiac injury.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Adams, J. E. Bodor, Geza S. Dávila-Román, Victor G. Delmez, James A. Apple, Fred S. Ladenson, Jack H. Jaffe, Allan S. |
| Copyright Year | 1993 |
| Abstract | BACKGROUND Levels of MBCK can be increased in patients with skeletal muscle injury or renal failure in the absence of myocardial injury, causing diagnostic confusion. This study was designed to determine whether measurement of cardiac troponin I (cTnI), a myocardial regulatory protein with comparable sensitivity to MBCK, has sufficient specificity to clarify the etiology of MBCK elevations in patients with acute or chronic skeletal muscle disease or renal failure. METHODS AND RESULTS Of the patients (n = 215) studied, 37 had acute skeletal muscle injury, 10 had chronic muscle disease, nine were marathon runners, and 159 were chronic dialysis patients. Patients were evaluated clinically, by ECG, and by two-dimensional echocardiography. Total creatine kinase (normal, < 170 IU/L) was determined spectrophotometrically, and cTnI (normal, < 3.1 ng/mL) and MBCK (normal, < 6.7 ng/mL) were determined with specific monoclonal antibodies. Values above the upper reference limit were considered "elevated." Elevations of total creatine kinase were common, and elevations of MBCK occurred in 59% of patients with acute muscle injury, 78% of patients with chronic muscle disease and marathon runners, and 3.8% of patients with chronic renal failure. Some of the patients were critically ill; five patients were found to have had myocardial infarctions and one had a myocardial contusion. cTnI was elevated only in these patients. CONCLUSIONS Elevations of cTnI are highly specific for myocardial injury. Use of cTnI should facilitate distinguishing whether elevations of MBCK are due to myocardial or skeletal muscle injury. |
| Starting Page | 1538 |
| Ending Page | 1538 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/88/1/101.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/88/1/101.full.pdf?download=true |
| PubMed reference number | 8319322v1 |
| Volume Number | 88 |
| Issue Number | 1 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cardiac troponin I Cardiomyopathies Chronic Obstructive Airway Disease Confusion Creatine Kinase Critical Illness Echocardiography Fifty Nine Kidney Failure, Chronic Monoclonal antibodies, antineoplastic Myalgia Myocardial Contusions Myocardial Infarction Myopathy Patients Renal Insufficiency TNNI3 wt Allele regulatory proteins |
| Content Type | Text |
| Resource Type | Article |
