NDLI: NMDA receptor antagonist d-APV depresses excitatory activity produced by normorphine in rat hippocampal slices

Content Provider	Semantic Scholar
Author	Swearengen, Elizabeth S. Chavkin, Charles
Copyright Year	1987
Abstract	Both pentylenetetrazole and normorphine increased CA1 pyramidal cell sensitivity to afferent stimulation and caused the appearance of synchronous afterpotentials (secondary spikes). D-2-Amino-5-phosphonovalerate (D-APV) attenuated secondary spikes induced by both drugs, but had no effect on the change in excitability of the primary population spike. These results suggest that both opiates and GABA receptor antagonists are able to unmask NMDA receptors in the in vitro rat hippocampus slice preparation.
Starting Page	80
Ending Page	84
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(87)90565-9
PubMed reference number	2886961
Journal	Medline
Volume Number	78
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394087905659
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394087905659?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2887%2990565-9
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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NMDA receptor antagonist d-APV depresses excitatory activity produced by normorphine in rat hippocampal slices