Anoxia selectively depresses excitatory synaptic transmission in hippocampal slices

Content Provider	Semantic Scholar
Author	Zhu, Ping Jun Krnjević, Krešimir
Copyright Year	1994
Abstract	EPSPs/IPSPs were recorded with intracellular electrodes from CA1 neurons close to site of stimulation. Brief anoxia (3 min) abolished EPSPs but reduced IPSPs by 64.8 +/- 4.0% (n = 10); the remaining IPSP was presumed to be monosynaptic. The effects of anoxia on purely monosynaptic IPSPs were examined after pharmacological blockade of excitatory synaptic transmission with 2 mM kynurenate or 20 microM CNQX + 20 microM APV. In these tests, after 3 min of anoxia the slopes of IPSPs vs. membrane potential were reduced by only 38.2 +/- 4.3% (n = 12). The present study demonstrates that, contrary to previous reports, inhibitory synaptic transmission is quite resistant to anoxia.
Starting Page	27
Ending Page	30
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(94)90832-X
PubMed reference number	7910678
Journal	Medline
Volume Number	166
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/030439409490832X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/030439409490832X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2894%2990832-X
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article