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Effect of 8-bromo-cyclic guanosine monophosphate (cGMP) on coronary artery constriction in isolated rabbit hearts.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Saeed, Maythem |
| Copyright Year | 1986 |
| Abstract | The vasodilator 8-bromo-guanosine 3':5'-monophosphate (8-bromo-cGMP) effectively counteracts vasopressin-induced coronary artery constriction in a supported perfused working rabbit heart. In this preparation, the coronary arteries remain in contact with the beating heart. The obtuse marginal artery and portions of the left anterior descending coronary artery were deprived of endothelium. Perfusion was carried out with Krebs-Henseleit solution, oxygenated with a disposable infant oxygenator. The internal diameter of large coronary arteries was determined by color arteriography (injection of patent blue dye and gated photography). The effect of vasopressin with and without the addition of 8-bromo-cGMP on cardiac performance (cardiac output, left ventricular systolic pressure, left ventricular end-diastolic pressure, maximal rate of rise in left ventricular pressure [dP/dtmax], mean aortic pressure) and large coronary vessel and total coronary vascular resistance was determined in nine experiments. In addition, changes in coronary sinus partial pressure of carbon dioxide (PCO2) and pH were observed. Vasopressin alone caused a significant decline in coronary flow, myocardial oxygen consumption and coronary sinus pH. Cardiac performance declined, probably because of myocardial ischemia. Large coronary vessel and total coronary vascular resistance rose. The vasodilator 8-bromo-cGMP strongly inhibited the vasoconstrictor action of vasopressin, counteracted the increase in large and total coronary vascular resistance, prevented the fall in myocardial oxygen consumption and eliminated changes in pH or PCO2 of coronary sinus effluent. Because of the elimination of myocardial ischemia by 8-bromo-cGMP, cardiac performance was normalized.(ABSTRACT TRUNCATED AT 250 WORDS) |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.onlinejacc.org/content/accj/8/2/342.full.pdf |
| PubMed reference number | 3016062v1 |
| Volume Number | 8 |
| Issue Number | 2 |
| Journal | Journal of the American College of Cardiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anterior descending branch of left coronary artery Aortic Valve Insufficiency Argipressin Arteriography Carbon dioxide measurement, partial pressure Cardiac Output Citric Acid Cycle Coronary Vessels Coronary sinus structure Cyclic GMP Diameter (qualifier value) Diastole Diastolic blood pressure Dyes Excretory function Guanosine Monophosphate Guanosine Tetraphosphate Heart Myocardial Ischemia Nasal sinus Oxygen Consumption Oxygenators Structure of obtuse marginal branch of circumflex branch of left coronary artery Systolic Pressure Vasoconstrictor Agents Vasodilator Agents patent blue violet |
| Content Type | Text |
| Resource Type | Article |
