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Does effective diastolic coronary venous retroperfusion depend on arterial-like blood pressure in the coronary sinus?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Verdouw, Pieter D. Beatt, Kevin J. Berk, Lee Serruys, P. W. |
| Copyright Year | 1988 |
| Abstract | We therefore conducted a series of experiments in which we looked at the effects of retroperfusion on Yorkshire pigs (18 to 45 kg), anesthetized and instrumented as described previously.4 The retroperfusion system (model EC-I, USCI division of CR. Bard) was set to pump 35 to 40 ml. min-1 of arterial blood retrogradely into the coronary sinus starting just before a Z&minute occlusion of the left anterior descending coronary artery. Within 2 minutes of occlusion, we observed in the control and retroperfusion groups similar decreases in cardiac output (-0.3 f 0.2 and 0.3 f 0.1 liter a min-I, respectively), mean arterial blood pressure (-12 f 3 and 12 f 3 mm Hg) and maximum rate of rise in left ventricular pressure (-370 f 90 and -450 f 60 mm Hg . s-l), and an increase in left ventricular end-diastolic blood pressure (4 f 1 and 3 f 1 mm Hg). These changes persisted during the remainder of the occlusion period. During reperfusion, the recovery of the hemodynamic parameters in both groups was similar in time and magnitude. In the untreated animals coronary artery occlusion resulted in a loss of systolic wall thickening (from 30 f 3 to 6 f 3%) within 2 minutes. No recovery was seen during the 2 first hours of reperfusion. Retroperfusion neither modified the loss of regional function during occlusion (from 32 f 3 to 5 f 3%) nor enhanced its recovery during reperfusion. In pigs, the residual flow after coronary artery Jigation is <5% of the preocclusion value and a reduction of flow to approximately 30% of baseline will result in a complete loss of function. This implies that retroperfusion must increase the flow to the ischemic area by at least this amount before any improvement in function can be expected. In the canine model it has been shown that 50% of the delivered retroperfusion flow is |
| Starting Page | 185 |
| Ending Page | 193 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://repub.eur.nl/pub/4284/eur_serruys_9062.pdf |
| PubMed reference number | 3364376v1 |
| Volume Number | 61 |
| Issue Number | 13 |
| Journal | The American journal of cardiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anterior descending branch of left coronary artery BaseLine dental cement Cardiac Output Coronary Occlusion Coronary sinus structure Diastole Hemodynamics Mercury Nasal sinus Occlusion of artery (disorder) Reperfusion Therapy Sinus - general anatomical term liter |
| Content Type | Text |
| Resource Type | Article |
