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Synthesis and characterization of a thermo-sensitive poly(N-methyl acryloylglycine methyl ester) used as a drug release carrier
| Content Provider | Semantic Scholar |
|---|---|
| Author | Deng, Kuilin Zhong, Haibin Jiao, Yi-Suo Fan, Ting Qiao, Xiao Zhang, Pengfei Ren, Xiaobo |
| Copyright Year | 2010 |
| Abstract | In this article, poly(N-methyl acryloylglycine methyl ester) (PNMAME) was prepared as a novel thermosensitive material with a lower critical solution temperature (LCST) at around 49.5°C. The chemical structures of the monomer NMAME and PNMAME were characterized by 1H NMR and IR measurements. The LCST was investigated systematically as a function of PNMAME concentration, inorganic salt solution and pH value. The results indicated that LCST of PNMAME was obviously dependent on PNMAME concentration and pH. The LCST was increased with a decrease in pH value and PNMAME concentration. To obtain a thermo-sensitive hydrogel with the phase transition temperature close to human body temperature, the copolymerization was conducted between NMAME and N-acryloylglycine ethyl ester (NAGEE). The release behavior of caffeine was evaluated at different temperatures and contents of cross-linkers (N, N-methylenebis(acrylamide) (NMBA)). The increase of cross-linker content led to a decrease in the release rate of caffeine due to higher crossing density in the hydrogel network. In addition, a faster release of caffeine from the hydrogel with 3% NMBA at 37°C was found in contrast to that at 18°C. |
| Starting Page | 164 |
| Ending Page | 170 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s11706-010-0032-1 |
| Volume Number | 4 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/s11706-010-0032-1 |
| Alternate Webpage(s) | https://doi.org/10.1007/s11706-010-0032-1 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
