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Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ma, Xin-Liang Tsao, Phil S. |
| Copyright Year | 1991 |
| Abstract | We studied the effects of MAbR15.7, an antibody directed against the common beta-chain (CD-18) of a family of neutrophil adherence glycoproteins, on endothelial dysfunction and myocardial injury in a model of myocardial ischemia and reperfusion in cats. Pentobarbital-anesthetized cats were subjected to 1.5 h occlusion of the left anterior descending coronary artery (LAD) and 4.5 h of reperfusion. MI + R resulted in severe myocardial injury and endothelial dysfunction, including significant elevation of plasma creatine kinase (CK) activity, marked myocardial necrosis, high cardiac myeloperoxidase (MPO) activity in ischemic cardiac tissue, and loss of response of LAD coronary rings to the endothelium-dependent vasodilators, acetylcholine (ACh) and A-23187. In contrast, MAbR15.7-treated cats exhibited a lower plasma CK activity at every time point observed after 2 h, a reduced area of cardiac necrosis (2 +/- 1 vs. 30.8 +/- 2.5% of area-at-risk, P less than 0.001), lower MPO activity in the ischemic region (P less than 0.01), and significantly preserved vasorelaxant responses of LAD coronary rings to endothelium-dependent vasodilators, ACh (P less than 0.001), and A-23187 (P less than 0.001). These results indicate that myocardial ischemia and reperfusion induces significant myocardial injury and endothelial dysfunction in the cat involving a CD18-dependent neutrophil adherence mechanism. Inhibition of neutrophil adherence to the endothelium exerts significant protective effects in this model of reperfusion injury. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/115000/115427/JCI91115427.pdf |
| PubMed reference number | 1680879v1 |
| Volume Number | 88 |
| Issue Number | 4 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | A-23187 Acetylcholine Anterior descending branch of left coronary artery Biologic Preservation Cardiomyopathies Creatine Kinase Endothelium Endothelium-Dependent Relaxing Factors Kidney Papillary Necrosis Myocardial Ischemia Pentobarbital Peroxidase Physiological reperfusion Reperfusion Injury Reperfusion Therapy Ring device Vasodilator Agents endothelial dysfunction neutrophil physical hard work |
| Content Type | Text |
| Resource Type | Article |
