Loading...
Please wait, while we are loading the content...
Similar Documents
Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cozzi, Emily Hazarika, Surovi Stallings, Howard W. Cascio, Wayne E. Devlin, Robert B. Lust, Robert M. Wingard, Christopher J. Scott, Michael R. Van |
| Copyright Year | 2006 |
| Abstract | Epidemiological studies have linked ambient particulate matter (PM) levels to an increased incidence of adverse cardiovascular events. Yet little is definitively known about the mechanisms accounting for the cardiovascular events associated with PM exposure. The goal of this study was to determine the effects of ultrafine (<0.1 microm) PM exposure on ischemia-reperfusion (I/R) injury. ICR mice were exposed to 100 microg of PM or vehicle by intratracheal instillation. Twenty-four hours later, mice were anesthetized with pentobarbital sodium (60 mg/kg), the left anterior descending coronary artery was ligated for 20 min, flow was restored for 2 h, and the resulting myocardial infarct (MI) size was evaluated. PM exposure doubled the relative size of the MI compared with the vehicle control. No difference was observed in the percentage of the left ventricle at risk for ischemia. PM exposure increased the level of oxidative stress in the myocardium after I/R. The density of neutrophils in the reperfused myocardium was increased by PM exposure, but differences in the number of blood leukocytes, expression of adhesion molecules on circulating neutrophils, and activation state of circulating neutrophils 24 h after PM exposure could not be correlated to the increased I/R injury observed. Additionally, aortas isolated from PM-exposed animals and studied in vitro exhibited a reduced endothelium-dependent relaxation response to acetylcholine. These results indicate that exposure to ultrafine PM increases oxidative stress in the myocardium, alters vascular reactivity, and augments injury after I/R in a murine model. |
| Starting Page | 97 |
| Ending Page | 103 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpheart.physiology.org/content/ajpheart/291/2/H894.full.pdf |
| PubMed reference number | 16582015v1 |
| Volume Number | 291 |
| Issue Number | 2 |
| Journal | American journal of physiology. Heart and circulatory physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acetylcholine Anterior descending branch of left coronary artery Aorta Cardiovascular Diseases Cerebral Hypoxia-Ischemia Heart Ventricle Ischemia Left ventricular structure Leukocytes Myocardial Infarction Myocardium Oxidative Stress Particulate (substance) Particulate Matter Pentobarbital Sodium Physiological reperfusion Reperfusion Injury neutrophil |
| Content Type | Text |
| Resource Type | Article |
