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Measurement of the position-dependent electrophoretic force on DNA in a glass nanocapillary.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bulushev, Roman D. Steinbock, Lorenz J. Khlybov, Sergey Steinbock, Julian F. Keyser, Ulrich F. Radenovic, Aleksandra |
| Copyright Year | 2014 |
| Abstract | The electrophoretic force on a single DNA molecule inside a glass nanocapillary depends on the opening size and varies with the distance along the symmetrical axis of the nanocapillary. Using optical tweezers and DNA-coated beads, we measured the stalling forces and mapped the position-dependent force profiles acting on DNA inside nanocapillaries of different sizes. We showed that the stalling force is higher in nanocapillaries of smaller diameters. The position-dependent force profiles strongly depend on the size of the nanocapillary opening, and for openings smaller than 20 nm, the profiles resemble the behavior observed in solid-state nanopores. To characterize the position-dependent force profiles in nanocapillaries of different sizes, we used a model that combines information from both analytical approximations and numerical calculations. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/nl503272r |
| PubMed reference number | 25343616 |
| Journal | Medline |
| Volume Number | 14 |
| Issue Number | 11 |
| Alternate Webpage(s) | https://infoscience.epfl.ch/record/205721/files/NanoLetters_Bulushev_2014.pdf |
| Alternate Webpage(s) | http://infoscience.epfl.ch/record/205721/files/NanoLetters_Bulushev_2014.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/nl503272r |
| Journal | Nano letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
