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Acute Coronary Syndromes in Treatment-Naı̈ve Black South Africans with Human Immunodeficiency Virus Infection
| Content Provider | Semantic Scholar |
|---|---|
| Author | Becker, Anthony Sliwa, Karen Stewart, S. Libhaber, Elena Essop, Ahmed Rashid Zambakides, C. A. Essop, Mohammed R. |
| Copyright Year | 2010 |
| Abstract | Background: HIV patients on protease inhibitors have greater risk of acute coronary syndromes (ACS) but little is known about treatment-naı̈ve patients. Methods and Results: Authors conducted a prospective single-center study from Soweto, South Africa, comparing the clinical and angiographic features of treatment-naı̈ve HIV positive and negative patients with ACS. Between March 2004 and February 2008, 30 consecutive treatment-naı̈ve HIV patients with ACS were compared to the next HIV-negative patient as a 1:1 control. HIV patients were younger (43 ± 7 vs. 54 ± 13, P = 0.004) and, besides smoking (73% vs. 33%, P = 0.002), had fewer risk factors than the control group with less hypertension (23% vs. 77%, P = 0.0001), diabetes (3% vs. 23% , P = 0.05), LDL hyperlipidemia (2.2 ± 0.9 vs. 3.0 ± 1.2, P = 0.006), and other coronary risk factors (7% vs. 53%, P = 0.0001). HDL was lower in the HIV group (0.8 ± 0.3 vs. 1.1 ± 0.4, P = 0.001). Atherosclerotic burden was lower in the HIV group with more normal infarct-related arteries (47% vs. 13%, P = 0.005) but a higher degree of large thrombus burden (43% vs. 17%, P = 0.02). Stents were used to a similar degree in HIV and control patients (30% vs. 37%, P = 0.78) with more target lesion revascularization in the HIV group (56% vs. 0%, P = 0.008). Conclusion: Treatment-naı̈ve HIV patients with ACS are younger and have fewer traditional risk factors than HIV-negative patients. HIV patients have less atherosclerotic but higher thrombotic burden which may imply a prothrombotic state in the pathogenesis of ACS in these patients. (J Interven Cardiol 2010;23:70–77) |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.hatter.uct.ac.za/sites/default/files/image_tool/images/292/Publications/2010/Acute.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
