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Sofosbuvir and daclatasvir
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hessel, Marleen Hanne Marieke Cohen, Adam F. Rissmann, Robert |
| Copyright Year | 2016 |
| Abstract | After entering hepatocytes, the viral genome of the hepatitis C virus (HCV) is translated into a single polypeptide. This polypeptide is subsequently cleaved into viral proteins, including non-structural (NS) proteins NS3, NS4A, NS5B and NS5B RNA dependent RNA polymerase (Figure 1) [3, 4]. These viral proteins are essential for viral replication and assembly making them significant targets for therapy. Sofosbuvir is the first available inhibitor of NS5B RNA dependent RNA polymerase. Daclatasvir is an inhibitor of NS5B. |
| Starting Page | 878 |
| Ending Page | 879 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 27198488 |
| Alternate Webpage(s) | https://doi.org/10.1111/bcp.13011 |
| DOI | 10.1111/bcp.13011 |
| Journal | British journal of clinical pharmacology |
| Volume Number | 82 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cleaved cell DNA-Directed RNA Polymerase Hepatitis C virus Polypeptides Viral Proteins Virus Replication daclatasvir non-T, non-B childhood acute lymphoblastic leukemia sofosbuvir |
| Content Type | Text |
| Resource Type | Article |