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Dysregulation of Phospholipid Metabolism in Synaptic Membranes and Their Role in Encephalopathy Forming After a Hemorrhagic Shock
| Content Provider | Semantic Scholar |
|---|---|
| Author | Leskova, Galina Fedorovna |
| Copyright Year | 2015 |
| Abstract | Phospholipids (PLs) of neuronal membranes are active universal neuromodulators. They regulate many functions of the neurons, including receptors signaling, which during a hemorrhagic shock (HS) get damaged, leading to encephalopathy. An analysis of the data, presented in this review, suggests that the dysregulation of PL metabolism in synaptic membranes is a key mechanism of encephalopathy during HS. Stabilizing the PL composition of the neuronal membranes may become one of the most important treatment methods for shock-induced disorders of brain functions. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20150304.13.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acoustic lobing Amino Acid Metabolism, Inborn Errors Brain Diseases CNS disorder Cognition Disorders Depletion region Electroconvulsive therapy Fetal Membranes, Premature Rupture Functional disorder Gene regulatory network Hyperactive behavior Medulla Oblongata Neurotoxicity Syndromes Nootropic Agents Phospholipids Shock, Hemorrhagic Synaptic Membranes Synaptic Package Manager Synaptic Transmission System Shock Tissue membrane Tree accumulation frontal lobe negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of synaptic vesicle uncoating |
| Content Type | Text |
| Resource Type | Article |