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Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Lijun Zhu, Shan An Li, Zhiyu Yuan, Jingping Yu, Dehua Xu, Zhiliang Li, Juanjuan Sun, Shengrong Wang, Changhua |
| Copyright Year | 2017 |
| Abstract | DNER, Delta/Notch-like epidermal growth factor (EGF)-related receptor, is a neuron-specific transmembrane protein carrying extracellular EGF-like repeats. The function of DNER in prostate cancer has not been evaluated. Here, we showed that the upregulation of DNER is observed in various cancers, including prostate cancer. Knockdown of DNER in PC-3 cells inhibited cell proliferation, migration and invasion as well as tumorigenesis in PC-3 xenografts. DNER knockdown specifically inhibited cell growth in spheroids. RT-PCR and western blot analysis were performed, and CD44, HES1 and GLI1 expression was significantly decreased in DNER knockdown cells. Thus, DNER promotes prostate cancer progression and the growth of PC-3 cells by modulating the primary genes of cancer stem cells. |
| Starting Page | 5031 |
| Ending Page | 5039 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29218101 |
| Journal | Medline |
| Volume Number | 9 |
| Issue Number | 11 |
| Alternate Webpage(s) | http://www.ajtr.org/files/ajtr0066151.pdf |
| Journal | American journal of translational research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
