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Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
| Content Provider | Semantic Scholar |
|---|---|
| Author | Greene, Maxwell Lai, Yongjie Pajcini, Kostandin V. Bailis, Will Pear, Warren S. Lancaster, Eric |
| Copyright Year | 2016 |
| Abstract | Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown. |
| File Format | PDF HTM / HTML |
| DOI | 10.1371/journal.pone.0161157 |
| PubMed reference number | 27622512 |
| Journal | Medline |
| Volume Number | 11 |
| Alternate Webpage(s) | https://www.be-md.ncbi.nlm.nih.gov/pmc/articles/PMC5021350/pdf/pone.0161157.pdf |
| Alternate Webpage(s) | https://doi.org/10.1371/journal.pone.0161157 |
| Journal | PloS one |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |