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The neglected avian hepatotropic virus induces acute and chronic hepatitis in ducks: an alternative model for hepatology
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ou, Xumin Mao, Sai Lan Cao, Jingyu Ma, Yunchao Ma, Guang-peng Cheng, Anchun Wang, Ming Shu Zhu, Dekang Chen, Shun Jia, Renyong Liu, Mafeng Sun, Kunfeng Yang, Qiao Wu, Ying Ping Chen, Xiaoyue |
| Copyright Year | 2017 |
| Abstract | Duck Hepatitis A Virus (DHAV) belongs to the Avihepatovirus, which is also classified into Picornaviridae with Hepatovirus, Hepatitis A Virus (HAV). In humans, the pathogenesis of HAV is not well understood because of limited work with animal models. Here, we investigated the progress of duck viral hepatitis caused by DHAV and their potential for dissecting the pathogenesis of HAV. During the course of infection, the duck model had undergone hepatocellular lesions (vacuolation, acidophilic degeneration and steatosis), lymphocytes recruitment (neutrophil granulocytes, heterophilic granulocytes and T cells or plasm cells) and repair (activation of hepatic stellate cells, fibrosis and regeneration). Coincident with liver injury, the serum biomarkers, aspartate aminotransferase and alanine transaminase were significantly increased. Moreover, comparatively lower CD4+ and CD8+ T-cells were recruited to the liver, which might lead to a persistent infection (40 wk). Because DHAV and HAV have similar genomic structure, biological phenotypes and can easily replicate in liver. And half of fibrosis-related genes had high homology between humans and ducks. Considering these similarity in pathological and virological phenotypes, we proposed that the ducks might be an alternatively small animal model that would provide insight into the pathogenesis of viral hepatitis, fibrosis and liver regeneration. |
| Starting Page | 81838 |
| Ending Page | 81851 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=19003&path%5B%5D=60907 |
| PubMed reference number | 5669852 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.19003 |
| DOI | 10.18632/oncotarget.19003 |
| Journal | Oncotarget |
| Volume Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alanine Transaminase Animal Model Aspartate Transaminase Aspartic Acid Aves Classification Duck hepatitis virus 1 Ducks Family Picornaviridae Fatty degeneration Fibrosis Granulocyte count Hepatitis A Virus Hepatitis, Chronic Hepatolenticular Degeneration Homologous Gene Liver diseases Natural regeneration Pathogenesis Phenotype Transaminases Viral hepatitis neutrophil |
| Content Type | Text |
| Resource Type | Article |
