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Perturbation du transport plasmatique des hormones thyroïdiennes par les contaminants environnementaux chez les femmes Inuit en âge de procréer du Nunavik
| Content Provider | Semantic Scholar |
|---|---|
| Author | Audet-Delage, Yannick |
| Copyright Year | 2013 |
| Abstract | The Inuit population of Nunavik (Northern Quebec, Canada) is highly exposed to persistent organic pollutants (POPs) through their traditional diet. Some POPs – i.e. hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs), pentachlorophenol (PCP) and perfluorooctane sulfonate (PFOS) compete with thyroxin (T4) for binding sites on transthyretin (TTR), a T4 transport protein found in plasma and cerebrospinal fluid. Displacement of T4 from TTR could result in decreased T4 delivery to the developing fetus, resulting in delayed growth and impaired neurodevelopment in infants. We tested the hypothesis that POPs or their metabolites decrease circulating concentrations of T4 bound to TTR (T4-TTR) in Inuit women of reproductive age. We measured the concentration of T4-TTR in plasma samples obtained from 120 Inuit women (18-39 years old) by combining |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://corpus.ulaval.ca/jspui/bitstream/20.500.11794/24922/1/29928.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
