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IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Tian Scully, Eileen P. Yin, Zhinan Kim, Jung H. Wang, Sha Mamula, Mark J. Anderson, John F. Craft, Joe Fikrig, Erol |
| Copyright Year | 2003 |
| Abstract | West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, thereby partially mimicking human disease. Using this model, we have demonstrated that mice deficient in γδ T cells are more susceptible to WN virus infection. TCRδ −/− mice have elevated viral loads and greater dissemination of the pathogen to the CNS. In wild-type mice, γδ T cells expanded significantly during WN virus infection, produced IFN-γ in ex vivo assays, and enhanced perforin expression by splenic T cells. Adoptive transfer of γδ T cells to TCRδ −/− mice reduced the susceptibility of these mice to WN virus, and this effect was primarily due to IFN-γ-producing γδ T cells. These data demonstrate a distinct role for γδ T cells in the control of and prevention of mortality from murine WN virus infection. |
| Starting Page | 2524 |
| Ending Page | 2531 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.4049/jimmunol.171.5.2524 |
| Volume Number | 171 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/171/5/2524.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.4049/jimmunol.171.5.2524 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
