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γδd T cells promote the maturation of dendritic cells during West Nile virus infection
| Content Provider | Scilit |
|---|---|
| Author | Fang, Hao Welte, Thomas Zheng, Xin Chang, Gwong-Jen J. Holbrook, Michael R. Soong, Lynn Wang, Tian |
| Copyright Year | 2010 |
| Description | Journal: FEMS Immunology and Medical Microbiology γδ T cells are important for the early control of West Nile virus (WNV) dissemination. Here, we investigated the role of γδ T cells in the regulation of $CD4^{+}$ T-cell response following a WNV challenge. Splenic dendritic cells (DCs) of WNV-infected γδ T-cell-deficient $(TCRδ^{−/−}$) mice displayed lower levels of CD40, CD80, CD86 and major histocompatibility complex (MHC) class II expression and interleukin-12 (IL-12) production than those of wild-type mice. Naïve DCs cocultured with WNV-infected γδ T cells showed enhanced levels of costimulatory molecules, MHC class II expression and IL-12 production. Further, coculture of $CD4^{+}$ T cells from OT II transgenic mice with DCs of WNV-infected $TCRδ^{−/−}$ mice induced less interferon-γ (IFN-γ) and IL-2 production than with those of wild-type controls. Viral antigens were detected in WNV-infected γδ T cells.WNV infection or toll-like receptor (TLR) agonist treatment of γδ T cells induced the production of IFN-γ, tumor necrosis factor-α and IL-6, which are known to promote DC maturation. Nevertheless, the levels of TLRs 2, 3, 4 and 7 expression of WNV-infected γδ T cells were not different from those of noninfected cells. Overall, these data suggest that WNV-induced γδ T-cell activation promotes DC maturation and initiates $CD4^{+}$ T-cell priming. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954433/pdf |
| Ending Page | 80 |
| Page Count | 10 |
| Starting Page | 71 |
| ISSN | 09288244 |
| e-ISSN | 1574695X |
| DOI | 10.1111/j.1574-695x.2010.00663.x |
| Journal | FEMS Immunology and Medical Microbiology |
| Issue Number | 1 |
| Volume Number | 59 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: FEMS Immunology and Medical Microbiology West Nile Virus Dendritic Cell Γδ T Cell |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Allergy Immunology Microbiology Microbiology (medical) |
