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MiR-323-5 p acts as a Tumor Suppressor by Targeting the Insulin-like Growth Factor 1 Receptor in Human Glioma Cells
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lian, Hai-Wei Zhou, Yun Jian, Zhi-Hong Liu, Ren-Zhong |
| Copyright Year | 2014 |
| Abstract | Gliomas are the most common primary brain tumors (Jansen et al., 2010), posing a disproportionately high mortality rate of more than 70% of cases in two years after diagnosis (Furnari et al., 2007). Also, GBM, classified as grade IV by the World Health Organization, is the most frequent and aggressive type with a median survival of 14 months, which is difficult to be treated and thus recurrences could arise nearly in each case (Wen et al., 2008). Despite novel insights and advances have been devoted to therapy, the prognosis of GBM patients still remains poor (Purow et al., 2009). The high recurrence rate and mortality of GBM make it urgent to investigate molecular mechanisms involved in GBM progression so as to develop the effective clinical therapies in GBM. IGF-1R is a transmembrane protein that contains two extracellular subunits with the ligand-binding site and two transmembrane subunits with intracellular tyrosine kinase activity (LeRoith et al., 2004). The up-regulation of IGF1R has been found in many types of cancers including glioma, and it could protect glioma cells from apoptosis (Resnicoff et al., 1995), suggesting that the inhibition of IGF-1R could be an effective way for glioma treatment. MicroRNAs (miRNAs) are the class of short, endogenous, non-coding RNA molecules that regulate the gene expression by binding with incomplete |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.apocpcontrol.org/paper_file/issue_abs/Volume15_No23/10181-10185%2010.1%20Hai-wei%20Lian.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
