NDLI: miR-1385 p acts as a tumor suppressor by targeting hTERT in human colorectal cancer

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miR-1385 p acts as a tumor suppressor by targeting hTERT in human colorectal cancer

Content Provider	Semantic Scholar
Author	Wang, Xiaotao Zhao, Yongkui Cao, Wenbin Wang, Changyou Sun, Bingfu Chen, Jianli Li, Shuguang Junmao Chen Cui, Mingxin Zhang, Bo Yang, Guanghua Liu, Yang Yu, Xiangyang Zhang, Guozhi
Copyright Year	2017
Abstract	Colorectal cancer (CRC) is the second most common cancer in the world. The incidence of this cancer is increasing in the developing countries. Mechanism of CRC tumorigenesis has been widely studied at the molecular levels, and has been recently proposed microRNAs as novel players in CRC. It has been reported that microRNA138-5p (miR-138-5p) play key roles in different kinds of human cancers. However, the roles and underlying molecular mechanisms of miR-138-5p in CRC have not been adequately elucidated. Thus, the aim of the present study was to investigate the roles and possible regulatory mechanisms of miR-138-5p in CRC. In this study, we demonstrated that miR-138-5p was significantly down-regulated in CRC tissue samples and cell lines. Functional analyses indicated that the overexpression of miR-138-5p significantly delayed cell proliferation, reduced colony formation and increased apoptosis in CRC cell lines. Moreover, human telomerase reverse transcriptase (hTERT), an important oncogene in the management of tumors, was confirmed as a direct target of miR-138-5p in CRC cells. We also found that the hTERT expression was increased in CRC tissues and was inversely correlated with miR-138-5p. Further study showed that the restoration of hTERT expression by an overexpressing plasmid could reverse the effects of miR-138-5p on proliferation and apoptosis of CRC cells. Taken together, these data defines a major suppresses proliferation and promotes apoptosis role for miR-138-5p, a microRNA functions as a tumor suppressor in CRC, by directly targeting hTERT, which would be provide a new strategy for future CRC therapies.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijcep.com/files/ijcep0062995.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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