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Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xue, Dengqi Xue, Yijie Yu, Haihua Shao, Liming |
| Copyright Year | 2019 |
| Abstract | A metal-free radical cyclization reaction of vinyl isocyanides with alkanes is developed, allowing convenient access to a diverse range of potentially valuable 1-alkylisoquinolines. The methodology is simple and efficient, demonstrating excellent functional group tolerance and broad substrate scope. A mechanism involving a radical process is supported by kinetic isotope effect and radical inhibition studies. |
| Starting Page | 874 |
| Ending Page | 884 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1055/s-0037-1610661 |
| Volume Number | 51 |
| Alternate Webpage(s) | https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0037-1610661.pdf |
| Alternate Webpage(s) | https://www.thieme-connect.com/media/synthesis/EFirst/supmat/sup_ss-2018-h0543-op_10-1055_s-0037-1610661.pdf |
| Alternate Webpage(s) | https://doi.org/10.1055/s-0037-1610661 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |