NDLI: The effects of MK-801, an NMDA receptor antagonist, on the micturition reflex in the rat

Please wait, while we are loading the content...

The effects of MK-801, an NMDA receptor antagonist, on the micturition reflex in the rat

Content Provider	Semantic Scholar
Author	Yoshiyama, Mitsuharu Roppolo, James R. Rihmland, J. Blastos, B. Groat, William C. De
Copyright Year	1991
Abstract	The effects of MK-801 (Dizocilpine) on the micturition reflex were studied in rats anesthetized with urethane (1.2 g/kg, s.c.). MK-801, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (1-1000 micrograms/kg, i.v.) reduced, in a dose-dependent fashion the amplitude of rhythmic bladder contractions recorded isovolumetrically via a transurethral catheter. The largest doses (300-1000 micrograms/kg) completely abolished bladder activity. Bilateral section of the hypogastric nerves had no effect on MK-801 induced inhibition. MK-801 did not inhibit the bladder contractions induced by electrical stimulation of the pelvic nerve. These data suggest that MK-801 acts in the central nervous system to block glutaminergic excitatory transmission in the central micturition reflex pathway.
Starting Page	141
Ending Page	144
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(91)90539-6
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394091905396
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394091905396?dgcid=api_sd_search-api-endpoint
PubMed reference number	1833672
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2891%2990539-6
Journal	Medline
Volume Number	126
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in