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Discovery of a cyclic 6 + 6 hexamer of D-biotin and formaldehyde
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lisbjerg, Micke Jessen, Bo M. Rasmussen, Brian Nielsen, Bjarne E. Madsen, Anders Ø. Pittelkow, Michael |
| Copyright Year | 2014 |
| Abstract | The discovery of receptors using templated synthesis enables the selection of strong receptors from complex mixtures. In this contribution we describe a study of the condensation of D-biotin and formaldehyde in acidic water. We have discovered that halide anions template the formation of a single isomer of a 6 + 6 macrocycle. The macrocycle (biotin[6]uril) is water-soluble, chiral and binds halide anions (iodide, bromide and chloride) with selectivity for iodide in water, and it can be isolated on a gram scale in a one-pot reaction in 63% yield. |
| Starting Page | 2647 |
| Ending Page | 2650 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C4SC00990H |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/sc/c4/c4sc00990h/c4sc00990h1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/C4SC00990H |
| Volume Number | 5 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
