NDLI: Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study.

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Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study.

Content Provider	Semantic Scholar
Author	Santis, Emiliana De Edwards, Alison A. Alexander, Bruce D. Holder, Simon J. Biesse-Martin, A. S. Nielsen, Birthe V. Mistry, Dharmit Waters, Laura J. Siligardi, Giuliano Hussain, Rohanah Faure, Sophie Taillefumier, Claude
Copyright Year	2016
Abstract	We describe the qualitative and quantitative analysis of the complexation properties towards cations of a cyclic peptoid hexamer composed of alternating α- and β-peptoid monomers, which bear exclusively chiral (S)-phenylethyl side chains (spe) that have no noticeable chelating properties. The binding of a series of monovalent and divalent cations was assessed by 1H NMR, circular dichroism, fluorescence and molecular modelling. In contrast to previous studies on cations binding by 18-membered α-cyclopeptoid hexamers, the 21-membered cyclopeptoid cP1 did not complex monovalent cations (Na+, K+, Ag+) but showed selectivity for divalent cations (Ca2+, Ba2+, Sr2+ and Mg2+). Hexacoordinated C-3 symmetrical complexes were demonstrated for divalent cations with ionic radii around 1 Å (Ca2+ and Ba2+), while 5-coordination is preferred for divalent cations with larger (Ba2+) or smaller ionic radii (Mg2+).
Starting Page	11371
Ending Page	11380
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1039/C6OB01954D
Alternate Webpage(s)	http://eprints.hud.ac.uk/30763/1/c6ob01954d.pdf
PubMed reference number	27805236
Alternate Webpage(s)	https://doi.org/10.1039/C6OB01954D
Journal	Medline
Volume Number	14
Issue Number	48
Journal	Organic & biomolecular chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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