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Utilization of L-alanine and L-glutamine by lactating mammary gland of the rat. A role for L-alanine as a lipogenic precursor.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Vina, Juan Williamson, Dermot H. |
| Copyright Year | 1981 |
| Abstract | 1. Lactation is associated with an increase in the arterial blood concentration of L-alanine and L-glutamate, but a decrease in that of L-glutamine compared with the corresponding values for virgin rats. 2. Virgin rats fed a 'cafeteria diet' that induces hyperphagia have increased arterial concentrations of L-alanine, L-glutamate and L-glutamine. During lactation L-alanine and L-glutamate concentrations are even higher. 3. The removal of L-alanine is decreased in hepatocytes from lactating rats fed either a chow or cafeteria diet. 4. Measurements of arteriovenous differences across lactating mammary glands indicate that appreciable amounts of L-glutamine and L-alanine are extracted by the gland. 5. A high proportion of the L-alanine metabolized by isolated acini from fed lactating rats is converted into lipid. 6. Metabolism of L-alanine in acini from starved lactating rats is limited by the activity of pyruvate dehydrogenase. 7. It is concluded that L-alanine and certain other amino acids taken up by the gland in excess of the requirements for protein synthesis can be converted into lipid. |
| File Format | PDF HTM / HTML |
| DOI | 10.1042/bj1960757 |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/196/3/757.full.pdf |
| PubMed reference number | 7317014 |
| Alternate Webpage(s) | https://doi.org/10.1042/bj1960757 |
| Journal | Medline |
| Volume Number | 196 |
| Issue Number | 3 |
| Journal | The Biochemical journal |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
