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Pyruvate Disposal by Lactating-Rat Mammary Gland
| Content Provider | Semantic Scholar |
|---|---|
| Author | Goheer, M. Anwar Coore, Haldane G. |
| Copyright Year | 1977 |
| Abstract | The fates of carbon atoms from pyruvate in lactating-rat mammary gland are shown in Scheme 1 (based on the review by Bauman &Davis, 1974). To avoid complicating the scheme we have not indicated that the major source of NADPH required for fatty acid synthesis is the hexose monophosphate shunt. In fact, oxidation ofglucose by the first two enzymes of this pathway is limited by the availability of NADP+ regenerated from NADPH by the activity of fatty acid synthetase. It is generally accepted that in nonruminants, including the rat, the major source of acetyl units in fatty acid synthesized by the mammary gland is plasma glucose via cytosolic pyruvate generated by the joint operation of the Embden-Meyerhof and hexose monophosphate-shunt pathways. Although Hawkins & Williamson (1972) could not detect significant uptake of plasma lactate by thegland insitu, this is a possiblealternative source of pyruvate, and both Katz et al. (1974) and Bartley & Abraham (1976) reported that, for lactating mammary parenchymal cells incubated in vitro, considerably higher rates of fatty acid synthesis were achieved when glucose and lactate were supplied compared with glucose alone, and that in the former situation exogenous lactate provided most of the carbon in the synthesized fatty acids. |
| Starting Page | 834 |
| Ending Page | 838 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1042/bst0050834 |
| Volume Number | 5 |
| Alternate Webpage(s) | http://www.biochemsoctrans.org/content/ppbiost/5/4/834.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1042/bst0050834 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
