NDLI: Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry

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Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry

Content Provider	Semantic Scholar
Author	Zhao, Xiulan Sun, Baocun Li, Yanlei Liu, Yanrong Zhang, Danfang Wang, Xudong Gu, Qiang Zhao, Jianmin Dong, Xueyi Liu, Zhiyong
Copyright Year	2015
Abstract	Vasculogenic mimicry (VM) is a functional microcirculation formed by tumor cells. Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, promote VM formation. Another specific MMP, collagenase-3 (MMP-13), has broad substrate specificity and potentially affects tumor metastasis and invasion. Here we found that MMP-13 was associated with metastasis and poor survival in 79 patients with melanoma. MMP-13 expression was inversely correlated with VM. These results were confirmed in human and mouse melanoma cell lines. We found that MMP-13 cleaves laminin-5 (Ln-5) into small fragments to accelerate tumor metastasis. Degradation of Ln-5 and VE-cadherin by MMP-13 inhibited VM formation. In conclusion, MMP-13 has a dual effect in melanoma, as it promotes invasion and metastasis but disrupts VM formation.
Starting Page	8890
Ending Page	8899
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/49/ae/oncotarget-06-8890.PMC4496190.pdf
Alternate Webpage(s)	http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=3189&path%5B%5D=6817
PubMed reference number	4496190
Volume Number	6
Journal	Oncotarget
Language	English
Access Restriction	Open
Subject Keyword	Cadherins Cultured Cell Line Dual Impotence, Vasculogenic Laminin MMP13 protein, human Matrix Metalloproteinase 13 Matrix Metalloproteinases Metalloproteases Microcirculation Neoplasm Metastasis Neoplasms Patients laminin-5 melanoma
Content Type	Text
Resource Type	Article

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