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Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | García-Arroyo, Fernando E. Tapia, Edilia Blas-Marron, Mónica G. Gonzaga, Guillermo Silverio, Octaviano Cristóbal, Magdalena Osorio, Horacio Arellano-Buendía, Abraham S. Zazueta, Cecilia Trejo, Omar Emiliano Aparicio‐ Reyes-García, Juan Gerardo Pedraza-Chaverri, José Soto, Virgilia Roncal-Jiménez, Carlos A. Johnson, Richard J. Sánchez-Lozada, Laura Gabriela |
| Copyright Year | 2017 |
| Abstract | Recurrent dehydration and heat stress cause chronic kidney damage in experimental animals. The injury is exacerbated by rehydration with fructose-containing beverages. Fructose may amplify dehydration-induced injury by directly stimulating vasopressin release and also by acting as a substrate for the aldose reductase-fructokinase pathway, as both of these systems are active during dehydration. The role of vasopressin in heat stress associated injury has not to date been explored. Here we show that the amplification of renal damage mediated by fructose in thermal dehydration is mediated by vasopressin. Fructose rehydration markedly enhanced vasopressin (copeptin) levels and activation of the aldose reductase-fructokinase pathway in the kidney. Moreover, the amplification of the renal functional changes (decreased creatinine clearance and tubular injury with systemic inflammation, renal oxidative stress, and mitochondrial dysfunction) were prevented by the blockade of V1a and V2 vasopressin receptors with conivaptan. On the other hand, there are also other operative mechanisms when water is used as rehydration fluid that produce milder renal damage that is not fully corrected by vasopressin blockade. Therefore, we clearly showed evidence of the cross-talk between fructose, even at small doses, and vasopressin that interact to amplify the renal damage induced by dehydration. These data may be relevant for heat stress nephropathy as well as for other renal pathologies due to the current generalized consumption of fructose and deficient hydration habits. |
| Starting Page | 961 |
| Ending Page | 975 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| DOI | 10.7150/ijbs.20074 |
| PubMed reference number | 28924378 |
| Journal | Medline |
| Volume Number | 13 |
| Alternate Webpage(s) | http://www.ijbs.com/v13/p0961/ijbsv13p0961s1.pdf |
| Alternate Webpage(s) | http://www.ijbs.com/v13p0961.pdf |
| Alternate Webpage(s) | https://doi.org/10.7150/ijbs.20074 |
| Journal | International journal of biological sciences |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
