NDLI: Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement.

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Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement.

Content Provider	Semantic Scholar
Author	Hu, Qinghua Wang, Chuang Li, Jian-Mei Zhang, Dong-Mei Kong, Ling-Dong
Copyright Year	2009
Abstract	Fructose consumption has been recently related to an epidemic of metabolic syndrome, and hyperuricemia plays a pathogenic role in fructose-induced metabolic syndrome. Fructose-fed rats showed hyperuricemia and renal dysfunction with reductions of the urinary uric acid/creatinine ratio and fractional excretion of uric acid (FE(ur)), as well as other features of metabolic syndrome. Lowering serum uric acid levels with allopurinol, rutin, and quercetin increased the urinary uric acid/creatinine ratio and FE(ur) and attenuated other fructose-induced metabolic abnormalities in rats, demonstrating that hyperuricemia contributed to the deficiency of renal uric acid excretion in this model. Furthermore, we found that fructose upregulated the expression levels of rSLC2A9v2 and renal-specific transporter (rRST), downregulated the expression levels of organic anion transporters (rOAT1 and rUAT) and organic cation transporters (rOCT1 and rOCT2), with the regulators prostaglandin E(2) (PGE(2)) elevation and nitric oxide (NO) reduction in rat kidney. Allopurinol, rutin, and quercetin reversed dysregulations of these transporters with PGE(2) reduction and NO elevation in the kidney of fructose-fed rats. These results suggested that dysregulations of renal rSLC2A9v2, rRST, rOAT1, rUAT, rOCT1, and rOCT2 contributed to fructose-induced hyperuricemia and renal dysfunction. Therefore, these renal transporters may represent novel therapeutic targets for the treatment of hyperuricemia and renal dysfunction in fructose-induced metabolic syndrome.
Starting Page	823
Ending Page	840
Page Count	18
File Format	PDF HTM / HTML
DOI	10.1152/ajprenal.90767.2008
PubMed reference number	19605544
Journal	Medline
Volume Number	297
Issue Number	4
Alternate Webpage(s)	http://ajprenal.physiology.org/content/ajprenal/297/4/f1080.full.pdf
Alternate Webpage(s)	http://ajprenal.physiology.org/content/ajprenal/early/2009/07/15/ajprenal.90767.2008.full.pdf
Alternate Webpage(s)	http://www.scientisthome.com/uploads/report/42.pdf
Alternate Webpage(s)	https://doi.org/10.1152/ajprenal.90767.2008
Journal	American journal of physiology. Renal physiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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