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Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements
| Content Provider | Semantic Scholar |
|---|---|
| Author | Antons, Jens Marascio, M. G. M. Nohava, J. Martin, Renaldo Applegate, Lee Ann Bourban, Pierre Pioletti, D. P. |
| Copyright Year | 2018 |
| Abstract | Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0.020 ± 0.003 MPa and 6.44 ± 1.02 MPa was measured. To validate the tissue quality, the histological tissue composition was visualized by glycosaminoglycan and collagen staining. This work aims to introduce a new protocol to investigate the zone-dependent mechanical properties of graded structures, such as human articular cartilage. From this knowledge, better cartilage repair strategies could be tailored in the future. |
| Starting Page | 1 |
| Ending Page | 8 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s10856-018-6066-0 |
| PubMed reference number | 29728770 |
| Journal | Medline |
| Volume Number | 29 |
| Alternate Webpage(s) | https://infoscience.epfl.ch/record/255013/files/Main.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s10856-018-6066-0 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
