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Prostate lymphoscintigraphy and radio-guided surgery for sentinel lymph node identification in prostate cancer. Technique and results of the first 350 cases.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wawroschek, Friedhelm Vogt, Harry Wengenmair, Hermann Weckermann, Dorothea Hamm, Michael Keil, Mathias Th. Graf, G. Heidenreich, Peter Harzmann, Rolf |
| Copyright Year | 2003 |
| Abstract | INTRODUCTION Having in mind the promising results of lymphoscintigraphy and intraoperative gamma probe application for the detection of sentinel lymph nodes (SLN) in malignant melanoma, breast and penis cancer, we tried to identify the SLN in prostate cancer by applying a comparable technique. MATERIALS AND METHOD 350 patients with prostate cancer were examined after providing informed consent. The day before pelvic lymphadenectomy technetium-99m nanocolloid was transrectally injected into the prostate under ultrasound guidance. A single central application was done per prostate lobe in most cases. Activity attained 90- 400 MBq, and the total injected volume was about 2-3 ml. Hereafter, lymphoscintigraphy was carried out. Those lymph nodes having been identified as SLN by means of gamma probe detection and lymphoscintigraphy were removed intraoperatively. Later, most of the cases had different types of pelvic lymphadenectomy. SLN received serial sections and immunohistochemistry, non-SLN step sections. RESULTS 335 patients showed at least 1 SLN in lymphoscintigraphy. 24.7% had lymph node metastases. In 2 patients, metastases in non-SLN were found without at least one SLN being affected (false-negative patient). CONCLUSION Our experience suggests that the SLN identification is not only feasible in breast cancer and malignant melanoma, but also in prostate cancer with a comparable technique. |
| Starting Page | 1951 |
| Ending Page | 1960 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://epub.ub.uni-muenchen.de/16320/1/10_1159_000070140.pdf |
| PubMed reference number | 12740496v1 |
| Volume Number | 70 |
| Issue Number | 4 |
| Journal | Urologia internationalis |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomic Node Consent Forms Lymph node excision Malignant neoplasm of penis Mammary Neoplasms Megabecquerel Patients Pelvic Inflammatory Disease Phase II/III Trial Prostatic Neoplasms Radioisotope scan of lymphatic system Sentinel Lymph Node Technetium 99m lymph nodes melanoma non-T, non-B, cALLa positive childhood acute lymphoblastic leukemia pelvic lymphadenectomy |
| Content Type | Text |
| Resource Type | Article |
