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Progesterone and Allopregnanolone in Male Amygdala-kindled Rats
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2018 |
| Abstract | The effect of intracerebroventricular administration of progesterone and its metabolite allopregnanolone(3a-hydroxy-5a-pregnane-20-one)on the amygdala kindling model of seizures was studied in male rats. Neither progesterone (10, 50, 200 �g/rat) nor allopregnanolone (12.5, 50, 100 �g/rat) had any effect on seizure parameters at 5, 15 and 30 min. after administration. Although previous studies imply the anticonvul sant effect of progesterone and its metabolite allopregnanolone against seizures induced by GABAA receptor antagonists, the present data do not support the anticonvulsant activity of these two steroids in amygdala-kindled seizures. MJIRI, Vol. 12, No.4, 377-380, 1999 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://mjiri.iums.ac.ir/article-1-991-en.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |